Fused dihydroxyquinoxalines and their use as glutamate antagonists

摘要: Heterocyclic dihydroxyquinoxaline compounds having the formula wherein R¹ and R² independently are hydrogen, NO₂, NH₂, CN, halogen, SO₂NH₂; -X-Y-Z- is selected from -N=N-NR³-,-NR³-N=N-,=N-NR³-N=,-S-CH=N-,-N=CH-S-,-CH=C(CO₂R³)­-S-,-S-C(CO₂R³)=CH-,=N-Se-N=, -N=CR³-NR³ -,-NR³-CR³=N-,=N-O-N=, -N=CR³-CR³ =N-,-NH-CR³=CR³-CR³=N-,-N=CR³-CR³=CR³-NH,=N-S-N=; wherein R³ lower alkyl, CF₃. The invention also relates to a method of preparing com­pounds, pharmaceutical compositions thereof, their use. useful in treatment indications caused by hyperactivity excitatory neurotransmitters.