An integrated view of cyclin E function and regulation.

摘要: Cancers of diverse cell lineages express high levels cyclin E, and in various studies, E overexpression correlates with increased tumor aggression. One way that normal control expression is disabled cancer cells via loss-of-function mutations sustained by FBXW7. This gene encodes the Fbw7 suppressor protein provides substrate specificity for a ubiquitin ligase complex targets multiple oncoproteins degradation. Numerous other mechanisms besides can deregulate activity cells. Recent reports demonstrate inappropriate may have far-reaching biological consequences physiology, including altering programs governing proliferation, differentiation, survival senescence. In this review, we discuss function mammalian context these new data as well network connects functions to cellular controls regulating its activity.