Apoptosis after traumatic human spinal cord injury
作者： Evelyne Emery , Philipp Aldana , Mary Bartlett Bunge , William Puckett , Anu Srinivasan
DOI: 10.3171/JNS.1998.89.6.0911
关键词:
摘要: Object. Apoptosis is a form of programmed cell death seen in variety developmental and disease states, including traumatic injuries. The main objective this study was to determine whether apoptosis observed after human spinal cord injury (SCI). spatial temporal expression apoptotic cells as well the nature involved were also investigated. Methods. authors examined cords 15 patients who died between 3 hours 2 months SCI. Apoptotic found at edges lesion epicenter adjacent white matter, particularly ascending tracts, by using histological (cresyl violet, hematoxylin eosin) nuclear staining (Hoechst 33342). presence supported with terminal deoxynucleotidyl transferase-mediated deoxyuridinetriphosphate nick-end labeling technique confirmed immunostaining for processed caspase-3 (CPP-32), member t...
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