Lomustine Nanoparticles Enable Both Bone Marrow Sparing and High Brain Drug Levels – A Strategy for Brain Cancer Treatments
作者： Funmilola A. Fisusi , Adeline Siew , Kar Wai Chooi , Omotunde Okubanjo , Natalie Garrett
DOI: 10.1007/S11095-016-1872-X
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摘要: Purpose The blood brain barrier compromises glioblastoma chemotherapy. However high concentrations of lipophilic, alkylating drugs result in uptake, but cause myelosuppression. We hypothesised that nanoparticles could achieve therapeutic without dose-limiting
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