Do common prothrombotic mutations influence the risk of cerebral ischaemia in patients with patent foramen ovale? - Systematic review and meta-analysis

摘要: Conflicting results are available on the association of prothrombotic genetic abnormalities with patent foramen ovale (PFO)- related cerebral ischaemia. We comprehensively sought and identified studies both factor V Leiden (FVG1691A mutation) prothrombin mutation (PTG20210A PFO-related ischaemia did metaanalyses to assess evidence for such a relation. analysed data from six eligible in 856 cases 1,001 control subjects. Additional unpublished new series including 463 subjects were also entered into analysis. The PTG20210A variant was significantly associated stroke comparison (odds ratio [OR] 3.85; 95% confidence interval [CI] 2.22 6.66) non-PFO-associated patients (OR 2.31; CI 1.20 4.43), whereas trend toward an observed FVG1691A 1.18; 0.73 1.90, compared subjects; OR 1.14; 0.62 2.09, patients). status carrier either or risk 1.98 (95% 1.38 2.83) 1.62 1.03 2.57), as patients, respectively. Addition common variants standard initial screening may contribute stratifying PFO-associated at different ischaemic events targeting secondary prevention strategies.