Mice deficient for N-ras: impaired antiviral immune response and T-cell function.

摘要: Ras proteins have a key role in the regulation of several cellular functions, and are involved significant percentage human tumors. However, specific functions different isoforms poorly understood. In this work, we show for first time N-ras T-cell function development. Mice defective low numbers CD8 single positive thymocytes decreased thymocyte proliferation vitro. signaling activation assays, KO-N-ras showed response to activation. turn, these deficiencies resulted reduction production interleukin 2 on We also detected vivo functional consequences deficiency. mice an increased sensitivity influenza infection, especially when doses virus were used. Finally, abnormal pattern downstream molecules receptor-activated that is consistent with found animals. All results derived from work constitute contribution knowledge N-ras-specific functions.