Transcatheter arterial chemoembolization or chemoinfusion for unresectable intrahepatic cholangiocarcinoma

摘要: BACKGROUND. The role of transcatheter arterial chemoembolization (TACE) or chemoinfusion (TACI) for unresectable intrahepatic cholangiocarcinoma (ICC) has recently been questioned. The aim the study was to evaluate clinical efficacy TACE TACI in patients with ICC and identify prognostic factors associated success. METHODS. From 1997 2007, 49 were treated (n = 124) 96). Tumor response evaluated based on computed tomography scans obtained 1 month 3 months after TACI. Factors success using multivariate logistic regression analysis. survival period Cox analysis. RESULTS. After treatment, 27 (55%) showed radiographic response. Multivariate analysis confirmed that tumor vascularity (odds ratio [OR], 31.2; P .002) only independent factor median mean periods our 12 24 months. analyses size (OR, 2.64; .048), 13.5; < .001), Child-Pugh class 3.65; .014) length period. CONCLUSIONS. Hepatic intra-arterial chemotherapy is well tolerated may be effective prolong ICC. significantly Large size, hypovascularity, B poor determining patient period. Cancer 2008. © 2008 American Society.