Liver Metastases of Neuroendocrine Tumors and CCC

摘要: With an increasing annual incidence of about 5/100,000, neuroendocrine tumors (NET) are relatively rare [1]. They originate from different types hormone-producing cells located not only in endocrine glands like the thyroid but almost every tissue. Even when NET can arise part body, lung (about 30 % all NETs) and gastroenteropancreatic system – so-called GEP (small intestine 17 %, colorectal 12 pancreatic 7 %) most common locations Especially, GEP-NETs often diagnosed at already advanced tumor stage (UICC IV) exhibiting liver metastases. There two groups hormonally inactive (70 active (30 that produce hormones including insulin (insulinoma), gastrin (gastrinoma), or serotonin. The patient’s clinical symptoms depend on type hormone produced: e.g., insulin, hypoglycemia; gastrin, peptic ulcers; serotonin, flush.