Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.

摘要: Abstract Chimeric mice in which lymphocytes are deficient the Syk tyrosine kinase have been created. Compared with Syk-positive controls, -/- display substantial depletion of intraepithelial gamma delta T cells skin and gut, developmental arrest occurring after antigen receptor gene rearrangement. In this dependence on Syk, subsets similar to B cells, but distinct from splenic that develop expand Syk-deficient mice. The characteristic associations certain T-cell V gamma/V rearrangements specific epithelia also disrupted by deficiency.