Defining the specific physiological requirements for c-Myc in T cell development
作者： Nataki C. Douglas , Harris Jacobs , Alfred L. M. Bothwell , Adrian C. Hayday
DOI: 10.1038/86308
关键词:
摘要: c-Myc is associated with cell growth and cycling in many tissues its deregulated expression causally implicated cancer, particularly lymphomagenesis. However, the contribution of to lymphocyte development unresolved. We show here that formation normal lymphocytes by c-Myc-/- cells selectively defective. are inefficient, an age-dependent manner, at populating thymus, subsequent thymocyte maturation ineffective: they fail grow proliferate normally late double-negative (DN) CD4-CD8- stage. Because N-Myc thymocytes usually declines DN stage, these results confirm nonredundant contributions Myc family members related their distinct patterns developmental gene expression.
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