Peripheral blood monocyte and T cell subsets in children with specific polysaccharide antibody deficiency (SPAD).

摘要: Specific polysaccharide antibody deficiency (SPAD) is a well reported immunodeficiency characterized by failure to produce antibodies against polyvalent antigens, expressed encapsulated microorganisms. The clinical presentation of these patients involves recurrent bacterial infections, being the most frequent agent Streptococcus (S.) pneumoniae. In SPAD few reports refer cells other than B cells. Since immune response S. pneumoniae and bacteria was historically considered restricted cells, seemed enough justify repetitive infections in patients. Our purpose determine if cell defects are accompanied leukocyte subpopulations necessary for development proper adaptive We here report that age related changes observed healthy children involving increased percentages classical monocytes (CD14++ CD16- cells) decreased intermediate CD16+ cells), absent Alterations can also be T supporting more complex what has been described up now.