Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi

作者: Pin Nie , Zubair Ahmed Laghari , Shan Nan Chen , Li Li , Bei Huang

DOI: 10.1016/J.DCI.2018.02.008

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摘要: Teleost fish are unique in having type I and type II interferons (IFNs) only, and the type I IFNs are classified into Group one and Group two based on the presence of two or four cysteines respectively, and are further classified into seven subgroups. In the present study, three distinct type I IFNs, IFNc, IFNd and IFNh, have been identified in the genome sequences of a perciform fish, the mandarin fish Siniperca chuatsi. These IFNs are induced following the stimulation of Polyinosinic polycytidylic acid (poly (I: C)) and Resiquimod (R848) either in …

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