Application of sucrose fatty acid esters in transdermal therapeutic systems.
作者： G. Csóka , S. Marton , R. Zelko , N. Otomo , I. Antal
DOI: 10.1016/J.EJPB.2006.07.009
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摘要: Abstract Transdermal therapeutic systems (TTSs) were studied applying different sucrose fatty acid esters (SEs) as drug delivery agents. Matrix and membrane controlled TTSs prepared compared. Membrane was made from a methacrylic polymer (Eudragit® NE) of pH independent permeability which can achieve diffusion liberation. Model water soluble β-blocker, metoprolol, has short biological half-life, so it in TTS, the duration its action could be prolonged. Sucrose chain lengths consequently hydrophilic–lipophilic balance (HLB) values considering their effect on metoprolol release TTSs. Different mathematical models applied for evaluation process. The results vitro studies indicated that SEs shorter length higher HLB value increased amount released about 10 times. promising agents transdermal to control cutaneous absorption.
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