A case-control study of occupational and environmental risk factors for Parkinson's disease in the Emilia-Romagna region of Italy.

摘要: A questionnaire-based case-control study was carried out on 86 patients with neurologist-confirmed idiopathic Parkinson's disease (PD) and controls similar in sex age. The control group recruited outpatient specialist centers of the same University Hospital (glaucoma, psoriasis vulgaris, essential arterial hypertension renal diseases). Exposure defined as occupational or residential contact a given factor for at least 10 consecutive years prior to onset PD. Smoking habits were by exclusion those subjects who never smoked. following risk factors identified: cranial trauma (OR: 2.88; 95% CI: 0.98-8.49), well water use 2.78; 1.46-5.28) exposure industrial chemicals 2.13; 1.16-3.91). Among chemicals, only organic solvents identified significant PD (O.R. : 2.78, C.I. 1.23-6.26). Whereas no neurotoxic metals occurred among controls, making assessment O.R. impossible, pesticides herbicides two groups 1.15; C. 0.56-2-36). negatively associated 0.41; 0.22-0.75), confirming "protective" role tobacco smoking suggested many studies. As whole, these results support environmental etiology