Das duktale Pankreaskarzinom und seine Vorläufer
作者： J. L�ttges , G. Kl�ppel
DOI: 10.1007/S00292-004-0735-0
关键词:
摘要: Das duktale Adenokarzinom des Pankreas ist der bei weitem haufigste maligne Pankreastumor. Es gehort zu den Tumoren mit schlechter Prognose. Die morphologischen Charakteristika sind: bevorzugte Lokalisation im Pankreaskopf, duktal-glandulare Tumorstrukturen verbunden ausgepragter Desmoplasie und CEA- MUC1-Positivitat. Varianten dieses Karzinoms sind das adenosquamose Karzinom, undifferenzierte pleomorphe Karzinom sowie gemischte duktal-endokrine Tumor. Mit Definition von Gangveranderungen als pankreatische intraepitheliale Neoplasie (PanIN) konnten ein Progressionsmodell fur die Entstehung duktalen Pankreaskarzinoms entwickelt korrespondierende Genalterationen nachgewiesen werden.
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