Fluoride-Induced Neuron Apoptosis and Expressions of Inflammatory Factors by Activating Microglia in Rat Brain
作者： Nan Yan , Yan Liu , Shengnan Liu , Siqi Cao , Fei Wang
DOI: 10.1007/S12035-015-9380-2
关键词:
摘要: Excessive exposure to fluoride results in structural and functional damages the central nervous system (CNS), neurotoxicity of may be associated with neurodegenerative changes. Chronic microglial activation appears cause neuronal damage through producing proinflammatory cytokines is involved many disorders. It not known about effects on microglia fluoride. In present study, healthy adult Wistar rats were exposed 60 120 ppm drinking water for 10 weeks, control received deionized water. After sacrificed under anesthesia then apoptosis neuron inflammatory factors secreted by determined. We found that neurons fluoride-treated rat brain increased terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-positive immunofluorescence increasing concentrations. Bax protein expression Bcl-2 decreased compared brain. The hippocampus cortex activated immunostaining OX-42, a marker microglia, OX-42-positive cells more abundant than cortex. levels IL-1β IL-6 OX-42-labeled significantly fluoride, TNF-α immunoreactivity was higher group group. Our indicate induced expressions activating
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