Maturation of peripheral arterial chemoreceptors in relation to neonatal apnoea

摘要: Apnoea and periodic breathing are the hallmarks of for infant who is born prematurely. Sustained respiration obtained through modulation respiratory-related neurons with inputs from periphery. The peripheral arterial chemoreceptors, uniquely reflexly change ventilation in response to changes oxygen tension. chemoreflex hypoxia hyperventilation, bradycardia vasoconstriction. fast time chemoreceptors carbon dioxide tension increases risk more periodicity pattern. As a result baseline hypoxaemia, contribute premature than term infants. While infants may have an augmented chemoreflex, develop bronchopulmonary dysplasia blunted at gestation. development chemosensitivity environmental factors that might cause maldevelopment continued maturation reviewed attempt help explain physiology apnoea prematurity increased incidence sudden death syndrome (SIDS) prematurely those exposed tobacco smoke.