Peripheral chemoreceptors: postnatal development and cytochemical findings in Sudden Infant Death Syndrome.

摘要: The aim of the present study is to give a review postnatal development peripheral chemoreceptors - carotid body, paraganglia, and pulmonary neuroendocrine cells (PNEC) with implications in Sudden Infant Death Syndrome (SIDS). In period, hypoxic chemosensitivity body gradually develops. Changes include proliferation type I II cells, increased numbers dense core vesicles K+ channels, modifications neurotransmitter/neuromodulator receptor expression. Chromaffin paraganglia show expression nitric oxide synthase neuropeptides, innervation. Innervation PNEC develops fully only first after which their density falls. neuropeptides produced by also changes, calcitonin gene-related peptide neuropeptide YY reduced gastrin-releasing peptide. Most findings SIDS victims, i.e., decrease cytoplasmic granules, increase progenitor indicates immaturity may play role form underlying biologic vulnerability. Aorticopulmonary hyperplasia are found SIDS, be epiphenomena alterations respiratory function pathogenetical SIDS. A comprehensive view pathogenesis should arise from integration neuro- cardiopathologic ones.