Deep brain stimulation of the subthalamic nucleus modulates reward processing and action selection in Parkinson patients.

摘要: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for motor impairments in Parkinson’s disease (PD) but its effect on motivational regulation action control still not fully understood. We investigated whether DBS STN influences ability PD patients to act anticipated reward or loss, improves execution independent valence. 16 (12 male, mean age = 58.5 ± 10.17 years) treated with bilateral STN-DBS and age- gender-matched group healthy controls (HC) performed a go/no-go task whose contingencies explicitly decouple valence action. Patients were tested (ON) without (OFF) active stimulation. For HC, there was benefit performing rewarded actions when compared that avoided punishment. showed such reliably only ON. In fact, relative behavioral go over avoid losing stronger under ON than HC. patients, rather generally improving functions valence, modulation by specifically rewards are anticipated. Thus, establishes reliable congruency between (“Pavlovian congruency”) remarkably enhances it level observed