Manipulation of the cabboxyl groups of α-amino-acids and peptides using radical chemistry based on esters of -hydroxy-2-thiopyridone

摘要: Abstract Photolysis of α-amino-acid or peptide esters derived from N -hydroxy-2-thiopyridone in the presence t -butylthiol affords expected decarboxylation products good yield. The reaction can be applied to α-carboxyl side chain carboxyl glutamic and aspartic acids thus permits preparation a number useful synthons. suitable halogen atom transfer reagent gives halides often yield and, especially case acid derivatives, without racemisation.