Notch signaling and development of the hematopoietic system.
作者： Ashley R. Sandy , Morgan Jones , Ivan Maillard
DOI: 10.1007/978-1-4614-0899-4_6
关键词:
摘要: Notch signaling exerts multiple important functions in the hematopoietic system. Notch1-mediated signals are essential to induce onset of definitive hematopoiesis within specialized domains hemogenic endothelium fetal dorsal aorta. In contrast, is dispensable for subsequent maintenance stem cells adult bone marrow. a key regulator early T-cell development thymus. An expanding number and lymphoid cell types have been reported receive context-dependent inputs from pathway that regulate their differentiation function. Progress field will continue bring fundamental information about practical insights into potential modulate therapeutic purposes.
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