Protective effects of cilazapril against free radical injury in myocardial ischaemia-reperfusion.

摘要: Cilazapril is a prodrug which rapidly hydrolysed to the pharmacologically active cilazaprilat following absorption bloodstream. In clinical pharmacological studies, administration of cilazapril resulted in potent, reversible, selective and competitive angiotensin converting enzyme inhibition. this study, we have examined protective effect on myocardial ischaemia-reperfusion model by using different parameters lipid peroxidation protein oxidation. We observed increased levels diene conjugates, carbonyls malondialdehyde as well after ischaemia-reperfusion, whereas sulphydryl groups were decreased. Our results clearly demonstrate that cilazapril, non-sulphydryl, long-acting inhibitor, has free-radical-scavenging potential comparable situation humans.