Influence of ACE inhibitors on free radicals and reperfusion injury: pharmacological curiosity or therapeutic hope?

摘要: 1. The currently available evidence shows that thiol containing ACE inhibitors are free radical (FR) scavengers in vitro; particular the OH. is effectively scavenged by these compounds. There also good that, vivo, can preserve myocardial contractile function following a period of reversible ischaemia (by directly protecting myocytes and/or preserving coronary flow through protection endothelial cells). These vivo benefits probably due to FR scavening, mainly presence group but, as consequence augmented prostanoid production. 2. Use more relevant animal models and testing range doses might be undertaken before clinical investigation considered. Because its nature, however, existence importance reperfusion injury man will only proven or disproven pharmacological intervention. One option compare agent with absent minimal haemodynamic effects placebo an adjunct thrombolysis. This simplest approach. An alternative approach conduct comparative study -SH inhibitor non given prior many problems either lack reliable measures activity difficulty measuring accurately left ventricular post-myocardial infarction means mortality likely end-point such study.(ABSTRACT TRUNCATED AT 250 WORDS)