Borage oil in the treatment of atopic dermatitis

摘要: Nutritional supplementation with omega-6 essential fatty acids (omega-6 EFAs) is of potential interest in the treatment atopic dermatitis. EFAs play a vital role skin structure and physiology. EFA deficiency replicates symptoms dermatitis, patients dermatitis have been reported to imbalances levels. Although direct proof lacking, it has hypothesized that impaired activity delta-6 desaturase enzyme, affecting metabolism linoleic acid gamma-linolenic (GLA). However, date, studies most commonly using evening primrose oil, produced conflicting results. Borage oil because contains two three times more GLA than oil. This review identified 12 clinical trials oral or topical borage for one preventive trial. All were controlled randomized double-blind, but many small had other methodological limitations. The results highly variable, effect be significant five studies, insignificant mixed studies. given at-risk neonates did not prevent development majority showed at least degree efficacy able exclude possibility produces benefit. Overall, data suggest nutritional unlikely major may useful some individual less severe who are seeking an alternative treatment. Which likely respond cannot yet identified. well tolerated short term no long-term tolerability available.