Identification of class I MHC-associated phosphopeptides as targets for cancer immunotherapy
作者： A. L. Zarling , J. M. Polefrone , A. M. Evans , L. M. Mikesh , J. Shabanowitz
关键词:
摘要: Alterations in phosphorylation of cellular proteins are a hallmark malignant transformation. Degradation these phosphoproteins could generate cancer-specific class I MHC-associated phosphopeptides recognizable by CD8+ T lymphocytes. In comparative analysis presented on the surface melanoma, ovarian carcinoma, and B lymphoblastoid cells, we find 5 36 that restricted to solid tumors common both cancers. Differential presentation peptides can result from differential source proteins. Recognition cancer cells phosphopeptide-specific lymphocytes validates potential as immunotherapeutic targets.
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J G Goossens, J P Van Wauwe, J R De Mey, OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties. Journal of Immunology. ,vol. 124, pp. 2708- 2713 ,(1980)
Gerard I. Evan, Karen H. Vousden, Proliferation, cell cycle and apoptosis in cancer Nature. ,vol. 411, pp. 342- 348 ,(2001) , 10.1038/35077213
Antonio Cruz, Methods and compositions using CD3 agonists ,(2005)
J.D. Marks, H.R. Hoogenboom, A.D. Griffiths, G Winter, Molecular evolution of proteins on filamentous phage. Mimicking the strategy of the immune system. Journal of Biological Chemistry. ,vol. 267, pp. 16007- 16010 ,(1992) , 10.1016/S0021-9258(18)41952-7
J Landry, H Lambert, M Zhou, J N Lavoie, E Hickey, L A Weber, C W Anderson, Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. Journal of Biological Chemistry. ,vol. 267, pp. 794- 803 ,(1992) , 10.1016/S0021-9258(18)48354-8
Jonathan Michael Boulter, Bent Karsten Jakobsen, Multivalent t cell receptor complexes ,(1999)
James D. Marks, Hennie R. Hoogenboom, Timothy P. Bonnert, John McCafferty, Andrew D. Griffiths, Greg Winter, By-passing immunization: Human antibodies from V-gene libraries displayed on phage Journal of Molecular Biology. ,vol. 222, pp. 581- 597 ,(1991) , 10.1016/0022-2836(91)90498-U
Paul J Sheskey, Marian E Quinn, Raymond C Rowe, Handbook of Pharmaceutical Excipients ,(1994)
Eva Krinner, Birgit Kohleisen, Christian Itin, Meera Berry, Patrick Bäuerle, Steven Zeman, Susanne Mangold, Roman Kischel, Peter Kufer, Tobias Raum, Human anti-human cd3 binding molecules ,(2004)
Cyrus Chothia, Jirí Novotný, Robert Bruccoleri, Martin Karplus, Domain association in immunoglobulin molecules. The packing of variable domains. Journal of Molecular Biology. ,vol. 186, pp. 651- 663 ,(1985) , 10.1016/0022-2836(85)90137-8