Review Article Factors Affecting Morphology of Skeletal Muscles
作者： L. TKÁâIKOVÁ , A. Tesfaye , I. Mikula
DOI:
关键词:
摘要: Tesfaye A., L. Tkaaikova, I. Mikula: Factors Affecting Morphology of Skeletal Muscles. Acta Vet. Brno 2005, 74: 153-159. Myostatin is a TGF-s family member. It plays negative role in regulating the growth skeletal muscles. The effects myostatin mutation adipose tissue are an indirect effect lack signaling muscle. An elucidation mechanism by which regulates fat metabolism vivo will ultimately require analysis genetically manipulated animals components pathway have been blocked specifically either muscle or tissue. Although expression level transgene was extremely low compared with muscle, it possible that this low-level sufficient to block fat. Several data suggest inhibitors such as follistatin and propeptide, activin type II receptor may be effective muscle-enhancing agents for both human agricultural applications.
vfu.cz 参考文章(20)
Alexandra C. McPherron, Ann M. Lawler, Se-Jin Lee, Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11 Nature Genetics. ,vol. 22, pp. 260- 264 ,(1999) , 10.1038/10320
Antonio Musarò, Karl McCullagh, Angelika Paul, Leslie Houghton, Gabriella Dobrowolny, Mario Molinaro, Elisabeth R. Barton, H. L Sweeney, Nadia Rosenthal, Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle Nature Genetics. ,vol. 27, pp. 195- 200 ,(2001) , 10.1038/84839
Daniel R. Marsh, David S. Criswell, James A. Carson, Frank W. Booth, Myogenic regulatory factors during regeneration of skeletal muscle in young, adult, and old rats Journal of Applied Physiology. ,vol. 83, pp. 1270- 1275 ,(1997) , 10.1152/JAPPL.1997.83.4.1270
E. P. Bottinger, V. M. Factor, M. L. Tsang, J. A. Weatherbee, J. B. Kopp, S. W. Qian, L. M. Wakefield, A. B. Roberts, S. S. Thorgeirsson, M. B. Sporn, The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 5877- 5882 ,(1996) , 10.1073/PNAS.93.12.5877
Martin M. Matzuk, Nalfang Lu, Hannes Vogel, Klaus Sellheyer, Dennis R. Roop, Allan Bradley, Multiple defects and perinatal death in mice deficient in follistatin Nature. ,vol. 374, pp. 360- 363 ,(1995) , 10.1038/374360A0
R. P. Woychik, M. L. Klebig, J. E. Wilkinson, J. G. Geisler, Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 4728- 4732 ,(1995) , 10.1073/PNAS.92.11.4728
Larry E. Gentry, Barry W. Nash, The pro domain of pre-pro-transforming growth factor beta 1 when independently expressed is a functional binding protein for the mature growth factor. Biochemistry. ,vol. 29, pp. 6851- 6857 ,(1990) , 10.1021/BI00481A014
Alexandra C. McPherron, Ann M. Lawler, Se-Jin Lee, Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. ,vol. 387, pp. 83- 90 ,(1997) , 10.1038/387083A0
Jens C Brüning, M.Dodson Michael, Jonathon N Winnay, Tatsuya Hayashi, Dieter Hörsch, Domenico Accili, Laurie J Goodyear, C.Ronald Kahn, A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance Molecular Cell. ,vol. 2, pp. 559- 569 ,(1998) , 10.1016/S1097-2765(00)80155-0
Robert E. Ferrell, Victor Conte, Elizabeth C. Lawrence, Stephen M. Roth, James M. Hagberg, Ben F. Hurley, Frequent Sequence Variation in the Human Myostatin (GDF8) Gene as a Marker for Analysis of Muscle-Related Phenotypes Genomics. ,vol. 62, pp. 203- 207 ,(1999) , 10.1006/GENO.1999.5984