Swords of cell death: caspase activation and regulation.
作者： Richard Kh Wyse , Faris Q Alenzi , Mahmoud Lotfy
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摘要: Apoptosis represents a crucial process in modulating organ development the embryo, homeostasis adult, and fostering appropriate immunological function. Caspases represent two central class of molecules that are either involved with stimulation apoptotic cascade (initiator caspases), or various sequential biological pathways required for its execution (effector caspases). With an eye towards therapeutic opportunities, this review discusses detail lineage initiator effector caspases, how they each activated, their substrates, regulation, maps out interact throughout from initiation first signal to final consequential breakdown cellular integrity.
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