Contra-Directional Expression of Plasma Superoxide Dismutase with Lipoprotein Cholesterol and High-Sensitivity C-reactive Protein as Important Markers of Parkinson's Disease Severity.
作者： Wanlin Yang , Zihan Chang , Rongfang Que , Guomei Weng , Bin Deng
关键词:
摘要: Aim: Oxidative stress and inflammation play critical roles in the neuropathogenesis of PD. We aimed to evaluate oxidative status by measuring serum superoxide dismutase (SOD) with lipoprotein cholesterol high-sensitivity C-reactive protein (hsCRP) respectively PD patients, explore their correlation disease severity. Methods: performed a cross-sectional study that included 204 patients age-matched healthy controls (HC). Plasma levels SOD, hsCRP, total cholesterol, high density (HDL-C) low (LDL-C) were measured. A series neuropsychological assessments rate severity Results: The plasma SOD (135.7±20.14 vs. 147.2±24.34, P<0.0001), HDL-C LDL-C significantly lower than those HCs; hsCRP level was remarkably increased compared HC (2.766±3.242 1.637±1.597, P<0.0001). negatively correlated while positively patients.The HY Besides, MoCA; MoCA respectively. Conclusion: Our findings suggest along LDL-C, higher might be important markers assess better understanding may yield insights into pathogenesis
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