Imaging Genomics of Glioblastoma: State of the Art Bridge Between Genomics and Neuroradiology

作者: Mohamed G. ElBanan , Ahmed M. Amer , Pascal O. Zinn , Rivka R. Colen

DOI: 10.1016/J.NIC.2014.09.010

关键词:

摘要: Glioblastoma (GBM) is the most common and aggressive primary malignant tumor of central nervous system. Recently, researchers concluded that "one-size-fits-all" approach for treatment GBM no longer valid research should be directed toward more personalized patient-tailored protocols. Identification molecular genomic pathways underlying essential achieving this targeted therapeutic approach. Imaging genomics represents a new era as noninvasive surrogate profile identification. This article discusses basics imaging GBM, its role in decision-making, future potential

参考文章(97)
Matthias C. Schmidt, Sven Antweiler, Nina Urban, Wolf Mueller, A. Kuklik, Birgit Meyer-Puttlitz, Otmar D. Wiestler, David N. Louis, Rolf Fimmers, Andreas von Deimling, Impact of Genotype and Morphology on the Prognosis of Glioblastoma Journal of Neuropathology and Experimental Neurology. ,vol. 61, pp. 321- 328 ,(2002) , 10.1093/JNEN/61.4.321
Anne G. Osborn, Diagnostic Imaging: Brain ,(2004)
Tiffany R. Hodges, Bryan D. Choi, Darell D. Bigner, Hai Yan, John H. Sampson, Isocitrate dehydrogenase 1: what it means to the neurosurgeon: A review Journal of Neurosurgery. ,vol. 118, pp. 1176- 1180 ,(2013) , 10.3171/2013.3.JNS122282
David N. Louis, WHO classification of tumours of the central nervous system International Agency for Research on Cancer. ,(2007)
Dirk Vordermark, Klemens Ruprecht, Peter Rieckmann, Wolfgang Roggendorf, Giles H Vince, Monika Warmuth-Metz, Oliver Kölbl, Michael Flentje, Glioblastoma multiforme with oligodendroglial component (GBMO): favorable outcome after post-operative radiotherapy and chemotherapy with nimustine (ACNU) and teniposide (VM26). BMC Cancer. ,vol. 6, pp. 247- 247 ,(2006) , 10.1186/1471-2407-6-247
A. James Barkovich, Anne G. Osborn, Karen L. Salzman, Comprar Diagnostic Imaging: Brain 2nd Ed | A. James Barkovich | 9781931884723 | Amirsys Amirsys. ,(2010)
S. Zhao, Y. Lin, W. Xu, W. Jiang, Z. Zha, P. Wang, W. Yu, Z. Li, L. Gong, Y. Peng, J. Ding, Q. Lei, K.-L. Guan, Y. Xiong, Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α Science. ,vol. 324, pp. 261- 265 ,(2009) , 10.1126/SCIENCE.1170944
Melike Mut, Ulku C. Turba, Anali Conesa Botella, Erol Baskurt, M. Beatriz S. Lopes, Mark E. Shaffrey, Neuroimaging Characteristics in Subgroup of GBMs with p53 Overexpression Journal of Neuroimaging. ,vol. 17, pp. 168- 174 ,(2007) , 10.1111/J.1552-6569.2007.00112.X
Kristin L. Bigos, Daniel R. Weinberger, Imaging genetics--days of future past. NeuroImage. ,vol. 53, pp. 804- 809 ,(2010) , 10.1016/J.NEUROIMAGE.2010.01.035