Hyperbaric oxygenation for tumour sensitisation to radiotherapy: a systematic review of randomised controlled trials.

摘要: Summary Background Radiotherapy is a well-established treatment for some solid tumours. Hyperbaric oxygenation (HBO) may improve radiotherapeutic killing of hypoxic cancer cells, so the simultaneous administration radiotherapy and HBO reduce mortality tumour recurrence. Methods We performed systematic search literature in September 2007 randomised controlled trials, made pooled analyses pre-determined clinical outcomes. Results Nineteen trials contributed to this review (2286 patients). There was reduction head neck cancers at one five years after therapy (at RR 0.82, P =0.03, NNT=5), improved local control three months (RR 0.58, =0.006, NNT=7). Any advantage achieved cost an increased rate both severe radiation tissue injury 2.35, NNH=22). Conclusions evidence that improves neck, recurrence uterine cervix. These benefits only occur with unusual fractionation schemes. associated significant adverse effects including oxygen toxic seizures injury. The methodological reporting inadequacies studies included demand cautious interpretation. More research needed head, cervical cancer, but probably not justified bladder cancer. little available concerning malignancies other sites.