Hyperbaric oxygen therapy for chronic radiation-induced tissue injuries: Australasia's largest study.

摘要: Aim Chronic radiation injuries, although uncommon, are associated with poor quality of life in oncology patients. The present study assesses the efficacy and safety hyperbaric oxygen therapy management chronic radiation-induced tissue injuries. Methods A retrospective analysis was performed 276 consecutive patients treated for injuries at Hyperbaric Medicine Unit, Townsville, Queensland, between March 1995 2008. Of these patients, 189 (68%) had complete follow-up data were assessed. Results A total 265 events injury experienced by therapy. Osteoradionecrosis prophylaxis due to dental disease an overall response rate 96% (P = 0.00003; Wilcoxon matched-pairs signed-rank test). rates established osteoradionecrosis mandible, soft necrosis head neck, xerostomia 86% (P = 0.00001), 85% (P = 0.002) 64% (P = 0.0001), respectively. other sites, proctitis hemorrhagic cystitis 84% (P = 0.03), 95% (P = 0.0001) complication after 15.9%, comprising reversible ear barotrauma (10.6%), ocular (4.2%), complications (0.5%) myocardial infarction (0.5%). Conclusion Our demonstrates that can be effectively used a variety injuries; its favorable risk profile suggests it should considered injuries.