作者: Vishnu Prasad Nelamangala Ramakrishnaiah , Srinivasan Krishnamachari
关键词: Radiation proctitis 、 Proctitis 、 Standard treatment 、 Surgery 、 Randomized controlled trial 、 Systematic review 、 Radiation therapy 、 Argon plasma coagulation 、 Clinical trial 、 Medicine
摘要: Chronic haemorrhagic radiation proctitis (CHRP) is a difficult problem faced by the patients following for pelvic malignancy. There no standard treatment this condition, but many methods of are available. The aim study was to review literature see whether there an improvement in available evidence comparison with previously published systematic reviews treating CHRP. PubMed/Medline database and Google Scholar search selectively searched. Studies, which treated rectal bleeding due chronic or CHRP, were included. Seventy studies finally selected out 14 randomized controlled clinical trials. Though these could not be compared, it seen that methodology studies. objective assessment symptoms, signs outcomes. But, still, only few looked into quality life To increase recruitment trials, national registry cases established late toxicity would facilitate further such Some conclusions reached based on 4% formalin should first line Formalin argon plasma coagulation (APC) equally effective, better severe disease. Refractory patients, responding APC, need referred hyperbaric oxygen therapy surgery. Radio-frequency ablation promising modality needs studied