Auditory deviance detection revisited: Evidence for a hierarchical novelty system

摘要: Abstract The fast detection of novel or deviant stimuli is a striking property the auditory processing which reflects basic organizational principles system and at same time high practical significance. In human electrophysiology, deviance has been related to occurrence mismatch negativity (MMN) — component event-related potential (ERP) evoked 100 250 ms after rare irregular sound. Recently, it shown in animal studies that considerable portion neurons pathway exhibits called stimulus-specific adaptation enabling them encode inter-sound relationships discharge higher rates changes acoustic stimulation. These neural responses have linked deviant-evoked measured scalp, but such occur lower levels anatomically (e.g. primary cortex as well inferior colliculi) are elicited earlier (20–30 ms sound onset) comparison MMN. Further, they not enough size be interpreted direct correlate We review here series recent findings provides first step toward filling this gap between recordings by showing comparably early modulations due sound's deviancy can observed humans, particularly middle-latency ERP within 50 ms onset. existence those indices preceding well-studied MMN strongly supports idea encoding regularities violations principle acting on multiple levels. This sustains notion hierarchically organized novelty system.