Distinct histological features characterize primary angiosarcoma of bone

摘要: Verbeke S L J, Bertoni F, Bacchini P, Sciot R, Fletcher C D M, Kroon H Hogendoorn P W & Bovee J V M G (2011) Histopathology 58, 254–264 Distinct histological features characterize primary angiosarcoma of bone Aims:  To define the criteria bone. Methods and results:  Forty-two angiosarcomas bone in 23 males 15 females were studied. Histological related to patients’ outcome. Eleven patients had multifocal lesions. Lesions located long short tubular bones followed by pelvis, spine trunk. Tumour cells positive for CD31 38 40, von Willebrand Factor 21 35, CD34 38, smooth muscle actin 22 36, D2–40 11 35 keratinAE1AE3 27 39. Thirty-nine tumours showed an epithelioid phenotype. One- 5-year survival rates 55% 33%, respectively. Survival analysis that a macronucleolus, three or more mitoses per 10 high-power field (HPF) fewer than five eosinophilic granulocytes HPF within tumour was associated with even worse compared overall group. Conclusions:  Because keratin positivity is seen majority cases, pathologists should avoid misinterpretation as metastatic carcinoma. A can be used further bone.