Distinct Chemokine Dynamics in Early Postoperative Period After Open and Robotic Colorectal Surgery

摘要: Stress response to robot-assisted colorectal surgery is largely unknown. Therefore, we conducted a prospective comparative nonrandomized study evaluating the perioperative dynamics of chemokines: IL-8/CXCL8, MCP-1/CCL2, MIP-1α/CCL3, MIP-1β/CCL4, RANTES/CCL5, and eotaxin-1/CCL11 in 61 cancer patients following open (OCS) or (RACS) reference clinical data. Postoperative IL-8 MCP-1 increase was reduced RACS with magnitude blood loss, length surgery, concomitant up-regulation IL-6 TNFα as its independent predictors. RANTES at 8 h dropped RANTES, MIP1α/β 24 were more elevated than OCS. 72 remained higher subsequently developing surgical site infections, whom 2.6- 2.5-fold observed. undergoing procedure predictive anastomotic leak (AL; 94% accuracy). Changes delayed restoration bowel function. Chemokines behave differently depending on procedure. A approach may be beneficial terms chemokine by favoring Th1 immunity attenuated angiogenic potential postoperative ileus. Monitoring prove useful for predicting adverse events. Attenuated results from less severe loss diminished inflammatory response.