Desferrithiocin analogs and uses thereof

摘要: Iron overload is associated with pathological conditions such as oxidative stress, transfusional iron overload, thalassemia, primary hemochromatosis, secondary diabetes, liver disease, heart cancer, radiation injury, neurological or neurodegenerative disorder, Friedreich's ataxia (FRDA), macular degeneration, closed head irritable bowel and reperfusion injury. The present invention provides methods pharmaceutical compositions using desferrithiocin analogs of Formulae (A) (J) for treating and/or preventing these conditions, metal (e.g., iron, aluminum, a lanthanide, an actinide uranium)) infectious diseases malaria).