The effect of desferrithiocin, an oral iron chelator, on T-cell function.

摘要: Desferrithiocin is a new, potent, orally available iron chelator. To determine whether this drug might be useful not only for iron-overload but also immunosuppression, we studied the in vitro effects of desferrithiocin on T-lymphocyte function. Like deferoxamine, inhibited, dose-dependent fashion, mitogen- and lectin-induced proliferation both human murine T cells. It was active at concentration 10 micrograms/mL. The inhibition reversed by ferrous chloride, other metal salts, recombinant IL-2, or conditioned medium. inhibited constitutively dividing, factor- independent EBV-transformed B cell leukemic T-cell lines. Although induction cytotoxic lymphocyte (CTL) activity, it did inhibit CTL- natural killer-induced cytotoxicity. agent expression activation antigens such as IL-2 receptor cells, nor early measures T- influx intracellular calcium. Thus, desferrithiocin, like potent reversible inhibitor proliferation. This anti-proliferative effect inhibits Bioavailability after oral administration unique property would make an attractive alternative to deferoxamine. Its immunomodulating properties may therefore exploited vivo graft rejection autoreactive