Alternative cerebrospinal fluid tests to diagnose neurosyphilis in HIV-infected individuals.
作者： C. M. Marra , L. C. Tantalo , C. L. Maxwell , K. Dougherty , B. Wood
DOI: 10.1212/01.WNL.0000131902.69113.34
关键词:
摘要: Objective: To identify alternatives to the CSF-Venereal Disease Research Laboratory (VDRL) test for diagnosis of neurosyphilis in HIV-infected individuals. Methods: CSF fluorescent treponemal antibody (FTA) reactivity and % lymphocytes that were B cells fresh frozen samples determined 47 cases with syphilis 26 controls. As serum, ≥2+ was considered positive. Based on results controls normal measures, cut-offs elevated proposed be ≥9% ≥20% samples. Neurosyphilis defined as a reactive CSF-VDRL. Results: CSF-FTA-ABS (absorbed) CSF-FTA (unabsorbed undiluted) 100% sensitive neurosyphilis. Elevated cryopreserved specific (100%) but not (40 43%) post hoc analyses. The assessment together allowed 16% pleocytosis nonreactive CSF-VDRL diagnosed 26% having Conclusion: When is nonreactive, may help exclude or establish
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