Angiogenesis Models Identify Factors Which Regulate Endothelial Cell Differentiation

摘要: During development, blood vessels are rapidly formed from angioblasts in the mesoderm. This is followed by extensive branching of to supply needs growing tissue. In adult, however, form a complex and stable network providing transit-way for cells, oxygen, growth factors, hormones, etc., all tissues. Usually changes vasculature occur only response injury stimulation, or cyclic female reproductive system. When induced become angiogenic, endothelial smooth muscle cells enter migratory proliferative phase resulting reorganization vessel wall formation new vessels. involves cascade sequential events leading cell invasion into underlying stroma, away parent towards stimulus 1,2 .