Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

作者: Lauren M. Billings , Salvatore Oddo , Kim N. Green , James L. McGaugh , Frank M. LaFerla

DOI: 10.1016/J.NEURON.2005.01.040

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摘要: … Furthermore, no deficits in either short-term or long-term memory were observed in the 1.5 and 24 hr spatial reference memory probe trials; we find that the 3xTg-AD mice performed as …

参考文章(45)
Chad A. Dickey, Marcia N. Gordon, Jerimiah E. Mason, Nedda J. Wilson, David M. Diamond, John F. Guzowski, Dave Morgan, Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice Journal of Neurochemistry. ,vol. 88, pp. 434- 442 ,(2003) , 10.1111/J.1471-4159.2004.02185.X
George Paxinos, Keith B. J. Franklin, The Mouse Brain in Stereotaxic Coordinates ,(2007)
Kenneth M. Lanzetta, Noriaki Yahata, Sebastian Pascarelle, Hsiao-Wen Chen, Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68 Nature. ,vol. 408, pp. 562- 564 ,(2000) , 10.1038/35046031
Chica Mori, Edward T. Spooner, Krystyna E. Wisniewski, Thomas M. Wisniewski, Haruyasu Yamaguchi, Takaomi C. Saido, Dean R. Tolan, Dennis J. Selkoe, Cynthia A. Lemere, Intraneuronal Aβ42 accumulation in Down syndrome brain Amyloid. ,vol. 9, pp. 88- 102 ,(2002) , 10.3109/13506120208995241
Dave Morgan, David M. Diamond, Paul E. Gottschall, Kenneth E. Ugen, Chad Dickey, John Hardy, Karen Duff, Paul Jantzen, Giovanni DiCarlo, Donna Wilcock, Karen Connor, Jaime Hatcher, Caroline Hope, Marcia Gordon, Gary W. Arendash, A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. ,vol. 408, pp. 982- 985 ,(2000) , 10.1038/35050116
Christopher Janus, Jacqueline Pearson, JoAnne McLaurin, Paul M. Mathews, Ying Jiang, Stephen D. Schmidt, M. Azhar Chishti, Patrick Horne, Donna Heslin, Janet French, Howard T.J. Mount, Ralph A. Nixon, Marc Mercken, Catherine Bergeron, Paul E. Fraser, Peter St George-Hyslop, David Westaway, Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease Nature. ,vol. 408, pp. 979- 982 ,(2000) , 10.1038/35050110
Akihide Mochizuki, Akira Tamaoka, Atsushi Shimohata, Yasuko Komatsuzaki, Shin'ichi Shoji, Aβ42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease The Lancet. ,vol. 355, pp. 42- 43 ,(2000) , 10.1016/S0140-6736(99)04937-5
Salvatore Oddo, Antonella Caccamo, Jason D Shepherd, M.Paul Murphy, Todd E Golde, Rakez Kayed, Raju Metherate, Mark P Mattson, Yama Akbari, Frank M LaFerla, Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles Neuron. ,vol. 39, pp. 409- 421 ,(2003) , 10.1016/S0896-6273(03)00434-3
R.J. Sutherland, R.J. McDonald, Hippocampus, amygdala, and memory deficits in rats. Behavioural Brain Research. ,vol. 37, pp. 57- 79 ,(1990) , 10.1016/0166-4328(90)90072-M
Yue Qi, Maho Morishima-Kawashima, Toru Sato, Rie Mitsumori, Yasuo Ihara, Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid β-protein 42 in chinese hamster ovary cells Biochemistry. ,vol. 42, pp. 1042- 1052 ,(2003) , 10.1021/BI0267590