Validation of Enhancing Effects of Curcumin on Radiotherapy with F98/FGT Glioblastoma-Bearing Rat Model.

摘要: Glioblastoma, the most common and aggressive brain tumor with low survival rate, is difficult to be cured by neurosurgery or radiotherapy. Mounting evidence has reported anti-inflammatory anticancer effects of curcumin on several types cancer in preclinical studies clinical trials. To our knowledge, there no platform system that could used effectively real-timely evaluate therapeutic efficacy for glioblastoma multiforme (GBM). In this study, we constructed a lentivirus vector triple-reporter genes (Fluc/GFP/tk) transduced into rat F98 cells establish an orthotopic F98/FGT glioma-bearing model. model, efficacies alone, radiation their combination were evaluated via noninvasive bioluminescent imaging overall measurements. At cell level, capable causing G2/M cycle arrest sensitizing radiation. animal synergistically enhances radiotherapy suppressing growth both transplanted glioma situ tumors, extending periods longer than those alone treatments. conclusion, have demonstrated may serve as novel radiosensitizer combine using model effective simultaneous evaluation efficacy.