摘要: Abstract Cancer is one of the most serious diseases that threaten human being today. To some degree, it a genetic disease but environmental and other nongenetic factors clearly play role in many stages neoplastic process. Genetic by themselves are thought to explain only about 5 % all cancer. The remainder can be attributed external, ‘environment’ act conjunction with both acquired susceptibility. Of note, part susceptibility owing variety genome. So, environment, genome cancer have much do each other. Combining information from epidemiology research works laboratory policy-making clinical works, purifying giving special protection high risk population, mortality may decrease gradually future.
harvard.edu
elsevier.com
sci-hub.se 参考文章(28)
H Mukhtar, N Ahmad, S Gupta, Prostate cancer chemoprevention by green tea. Seminars in Urologic Oncology. ,vol. 17, pp. 70- 76 ,(1999)
G.J. Kelloff, C.C. Sigman, P. Greenwald, Cancer chemoprevention European Journal of Cancer. ,vol. 35, pp. 1755- 1762 ,(1999) , 10.1016/S0959-8049(99)00164-1
Vidar Skaug, Aage Haugen, David Ryberg, Lodve Stangeland, Sigrid Lystad, Anne-Lise Børresen, Inderjit Mercy, Elin Kure, p53 Mutations in Lung Tumors: Relationship to Putative Susceptibility Markers for Cancer Cancer Research. ,vol. 54, pp. 1551- 1555 ,(1994)
S Venitt, Mechanisms of carcinogenesis and individual susceptibility to cancer. Clinical Chemistry. ,vol. 40, pp. 1421- 1425 ,(1994) , 10.1093/CLINCHEM/40.7.1421
Kei Nakachi, Takao Sekiya, Kaname Kawajiri, Mitsunobu Yamamoto, Hidetaka Eguchi, Association of CYP1A1 Germ Line Polymorphisms with Mutations of the p53 Gene in Lung Cancer Cancer Research. ,vol. 56, pp. 72- 76 ,(1996)
F. P. Perera, Environment and Cancer: Who Are Susceptible? Science. ,vol. 278, pp. 1068- 1073 ,(1997) , 10.1126/SCIENCE.278.5340.1068
A. M. Ford, C. A. Bennett, C. M. Price, M. C. A. Bruin, E. R. Van Wering, M. Greaves, Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 4584- 4588 ,(1998) , 10.1073/PNAS.95.8.4584
DANIEL W. NEBERT, ROSS A. MCKINNON, ALVARO PUGA, Human Drug-Metabolizing Enzyme Polymorphisms: Effects on Risk of Toxicity and Cancer DNA and Cell Biology. ,vol. 15, pp. 273- 280 ,(1996) , 10.1089/DNA.1996.15.273
Jane E. Sande, Robert J. Arceci, Beatrice C. Lampkin, Congenital and neonatal leukemia Seminars in Perinatology. ,vol. 23, pp. 274- 285 ,(1999) , 10.1016/S0146-0005(99)80036-6
William P. Bennett, S. Perwez Hussain, Kirsi H. Vahakangas, Mohammed A. Khan, Peter G. Shields, Curtis C. Harris, Molecular epidemiology of human cancer risk: gene–environment interactions and p53 mutation spectrum in human lung cancer The Journal of Pathology. ,vol. 187, pp. 8- 18 ,(1999) , 10.1002/(SICI)1096-9896(199901)187:1<8::AID-PATH232>3.0.CO;2-Y