Association between PLCE1 rs2274223 A > G polymorphism and cancer risk: proof from a meta-analysis
作者： Wenji Xue , Meiling Zhu , Yiwei Wang , Jing He , Leizhen Zheng
DOI: 10.1038/SREP07986
关键词:
摘要: Phospholipase C epsilon 1 (PLCE1) plays an important role in cell growth, differentiation and oncogenesis. An increasing number of individual studies have investigated the association between PLCE1 rs2274223 polymorphism cancer risk, but conclusions are inconclusive. To obtain a comprehensive conclusion, we performed meta-analysis 22 with 13188 cases 14666 controls. The pooled results indicated that A > G was associated increased risk overall (G vs. A: OR = 1.15, 95% CI 1.06–1.25; GG AA: 1.30, 1.10–1.55; GA 1.18, 1.08–1.30; GG/GA 1.20, 1.08–1.32; GA/AA: 1.22, 1.04–1.42). stratification analysis showed significantly esophageal squamous carcinoma (ESCC) other than gastric (GC), especially among subgroups Asian, high quality score, sample size 1000 consistent Hardy-Weinberg equilibrium (HWE). This demonstrated may be susceptibility to cancer, for ESCC. However, due substantial heterogeneities across studies, conclusion might not conclusive need more confirm.
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