Spatially clustered loci with multiple enhancers are frequent targets of HIV-1
作者： Bojana Lucic , Heng-Chang Chen , Maja Kuzman , Eduard Zorita , Julia Wegner
DOI: 10.1101/287896
关键词:
摘要: HIV-1 recurrently targets active genes that are positioned in the outer shell of nucleus and integrates proximity nuclear pore compartment. However, genomic features these relevance their transcriptional activity for integration have so far remained unclear. Here we show targeted delineated with super-enhancer elements they cluster specific spatial compartments T cell nucleus. We further gene clusters acquire location at periphery during activation cells. The clustering along major determinants Our results first time compartmentalization genome integration, thus strengthening role architecture viral infection.
sci-hub.st 参考文章(99)
SH Hughes, HE Varmus, JM Coffin, The Interactions of Retroviruses and their Hosts Cold Spring Harbor Laboratory Press. ,(1997)
Steven Witte, John J. O'Shea, Golnaz Vahedi, Super-enhancers: Asset management in immune cell genomes Trends in Immunology. ,vol. 36, pp. 519- 526 ,(2015) , 10.1016/J.IT.2015.07.005
Gilles Darcis, Anna Kula, Sophie Bouchat, Koh Fujinaga, Francis Corazza, Amina Ait-Ammar, Nadège Delacourt, Adeline Melard, Kabamba Kabeya, Caroline Vanhulle, Benoit Van Driessche, Jean-Stéphane Gatot, Thomas Cherrier, Luiz F. Pianowski, Lucio Gama, Christian Schwartz, Jorge Vila, Arsène Burny, Nathan Clumeck, Michel Moutschen, Stéphane De Wit, B. Matija Peterlin, Christine Rouzioux, Olivier Rohr, Carine Van Lint, An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression PLOS Pathogens. ,vol. 11, pp. e1005063- ,(2015) , 10.1371/JOURNAL.PPAT.1005063
Robert E Thurman, Eric Rynes, Richard Humbert, Jeff Vierstra, Matthew T Maurano, Eric Haugen, Nathan C Sheffield, Andrew B Stergachis, Hao Wang, Benjamin Vernot, Kavita Garg, Sam John, Richard Sandstrom, Daniel Bates, Lisa Boatman, Theresa K Canfield, Morgan Diegel, Douglas Dunn, Abigail K Ebersol, Tristan Frum, Erika Giste, Audra K Johnson, Ericka M Johnson, Tanya Kutyavin, Bryan Lajoie, Bum-Kyu Lee, Kristen Lee, Darin London, Dimitra Lotakis, Shane Neph, Fidencio Neri, Eric D Nguyen, Hongzhu Qu, Alex P Reynolds, Vaughn Roach, Alexias Safi, Minerva E Sanchez, Amartya Sanyal, Anthony Shafer, Jeremy M Simon, Lingyun Song, Shinny Vong, Molly Weaver, Yongqi Yan, Zhancheng Zhang, Zhuzhu Zhang, Boris Lenhard, Muneesh Tewari, Michael O Dorschner, R Scott Hansen, Patrick A Navas, George Stamatoyannopoulos, Vishwanath R Iyer, Jason D Lieb, Shamil R Sunyaev, Joshua M Akey, Peter J Sabo, Rajinder Kaul, Terrence S Furey, Job Dekker, Gregory E Crawford, John A Stamatoyannopoulos, None, The accessible chromatin landscape of the human genome Nature. ,vol. 489, pp. 75- 82 ,(2012) , 10.1038/NATURE11232
Eric J. Wagner, Phillip B. Carpenter, Understanding the language of Lys36 methylation at histone H3 Nature Reviews Molecular Cell Biology. ,vol. 13, pp. 115- 126 ,(2012) , 10.1038/NRM3274
Warren A. Whyte, David A. Orlando, Denes Hnisz, Brian J. Abraham, Charles Y. Lin, Michael H. Kagey, Peter B. Rahl, Tong Ihn Lee, Richard A. Young, Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes Cell. ,vol. 153, pp. 307- 319 ,(2013) , 10.1016/J.CELL.2013.03.035
Suhas SP Rao, Miriam H Huntley, Neva C Durand, Elena K Stamenova, Ivan D Bochkov, James T Robinson, Adrian L Sanborn, Ido Machol, Arina D Omer, Eric S Lander, Erez Lieberman Aiden, None, A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping Cell. ,vol. 159, pp. 1665- 1680 ,(2014) , 10.1016/J.CELL.2014.11.021
Gregory M. Laird, C. Korin Bullen, Daniel I.S. Rosenbloom, Alyssa R. Martin, Alison L. Hill, Christine M. Durand, Janet D. Siliciano, Robert F. Siliciano, Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations Journal of Clinical Investigation. ,vol. 125, pp. 1901- 1912 ,(2015) , 10.1172/JCI80142
Amit Sharma, Ross C Larue, Matthew R Plumb, Nirav Malani, Frances Male, Alison Slaughter, Jacques J Kessl, Nikolozi Shkriabai, Elizabeth Coward, Sriram S Aiyer, Patrick L Green, Li Wu, Monica J Roth, Frederic D Bushman, Mamuka Kvaratskhelia, BET proteins promote efficient murine leukemia virus integration at transcription start sites Proceedings of the National Academy of Sciences of the United States of America. ,vol. 110, pp. 12036- 12041 ,(2013) , 10.1073/PNAS.1307157110
Bruna Marini, Attila Kertesz-Farkas, Hashim Ali, Bojana Lucic, Kamil Lisek, Lara Manganaro, Sandor Pongor, Roberto Luzzati, Alessandra Recchia, Fulvio Mavilio, Mauro Giacca, Marina Lusic, Nuclear architecture dictates HIV-1 integration site selection Nature. ,vol. 521, pp. 227- 231 ,(2015) , 10.1038/NATURE14226