Magnetization transfer histogram parameters reflect all dimensions of MS pathology, including atrophy.

摘要: Introduction: Magnetization transfer ratio (MTR) histogram analysis can be used as a method for quantifying overall disease burden in MS. We studied correlations between MTR and clinical parameters MS subgroups. Contrary to earlier studies we placed special emphasis on the lower range, explore effect of partial volume averaging effects with CSF. Methods: Seventy-nine patients [26 primary progressive (PP), 53 'relapse-onset', including 26 secondary (SP)], 23 healthy individuals were studied. MR imaging included 3 mm 2D gradient-echo images without an off-resonance MT pulse. According visually determined cut-off, classified parenchymal or CSF-related variables. Clinical measurements Expanded Disability Status Scale (EDSS) measure global impairment/disability Paced Auditory Serial Addition Test (PASAT) cognition. Results: SP differed from other subgroups many variables, originating both higher range. low MTRs clearly over-represented patients, showed significant distinction PP group. In total group, well relapse-onset found parameters. No associations Conclusion: This explorative study suggests that distinguish controls, best identifies phenotype, partly result increased CSF (atrophy). addition, show gives information about level impairment disability 'relapse-onset' course MS, therefore provides useful tool monitor evolution these patients.