Integrative aspects of zinc transporters.

摘要: Cells maintain zinc concentrations with relatively narrow limits. Nevertheless, physiologically relevant changes in free Zn(II) pools or Zn bound to specific ligands within vesicles may occur without a major change total cellular concentrations. The task of maintaining such levels rests part transporter proteins. genes for some putative transporters have recently been cloned. As this time, most not directly shown transport functional studies, albeit evidence is strong that they function. Zinc (ZnT)-1 was identified as rescue agent cells maintained very high extracellular conditions; therefore, ZnT-1 has suggested function an exporter. expressed variety tissues, including intestine, kidney and liver. Intestinal expression regional, being much greater duodenum jejunum villus versus crypt cells. Immunolocalization places at the basolateral membrane intestinal enterocytes epithelial distal renal tubules. Regulation mRNA protein does markedly dietary level except when large single oral supplement provided. induced by transient ischemia forebrain. ZnT-2 ZnT-3 tissue-specific vesicular transport. ZnT-4 believed be abundant mammary gland associated secretion into milk. A mutation gene account lethal milk (Im) syndrome. thus far appear characteristics commensurate functions integrative acquisition homeostasis.