Annotation, genetics and transcriptomics

作者: R. Mott

DOI: 10.1007/978-3-211-75123-7_7

关键词:

摘要: This chapter discusses how to combine genome annotations of the type described elsewhere in this book with genetic and functional genomics data find genes associated a phenotype, particular complex disease. problem is fundamental importance; promise that understanding molecular basis common diseases would lead effective treatments helped motivate fund human project.

参考文章(31)
Manas K. Ray, Shawn P. Fagan, F. Charles Brunicardi, The Cre-loxP system: a versatile tool for targeting genes in a cell- and stage-specific manner. Cell Transplantation. ,vol. 9, pp. 805- 815 ,(2000) , 10.1177/096368970000900607
Christopher L. Karp, Andrew Grupe, Eric Schadt, Susan L. Ewart, Michelle Keane-Moore, Peter J. Cuomo, Jörg Köhl, Larry Wahl, Douglas Kuperman, Soren Germer, Dee Aud, Gary Peltz, Marsha Wills-Karp, Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nature Immunology. ,vol. 1, pp. 221- 226 ,(2000) , 10.1038/79759
N. Bradshaw, C. Brewer, G. Brice, B. Bullman, J. Campbell, B. Castle, R. Cetnarsryj, C. Chapman, C. Chu, N. Coates, T. Cole, R. Davidson, A. Donaldson, H. Dorkins, F. Douglas, D. Eccles, R. Eeles, F. Elmslie, D. G. Evans, S. Goff, S. Goodman, D. Goudie, J. Gray, L. Greenhalgh, H. Gregory, S. V. Hodgson, T. Homfray, R. S. Houlston, L. Izatt, L. Jackson, L. Jeffers, V. Johnson-Roffey, F. Kavalier, C. Kirk, F. Lalloo, C. Langman, I. Locke, M. Longmuir, J. Mackay, A. Magee, S. Mansour, Z. Miedzybrodzka, J. Miller, P. Morrison, V. Murday, J. Paterson, G. Pichert, M. Porteous, N. Rahman, M. Rogers, S. Rowe, S. Shanley, A. Saggar, G. Scott, L. Side, L. Snadden, M. Steel, M. Thomas, S. Thomas, M. I. McCarthy, A. T. Hattersley, , E. Zeggini, M. N. Weedon, C. M. Lindgren, T. M. Frayling, K. S. Elliott, H. Lango, N. J. Timpson, J. R. B. Perry, N. W. Rayner, R. M. Freathy, J. C. Barrett, B. Shields, A. P. Morris, S. Ellard, C. J. Groves, L. W. Harries, J. L. Marchini, K. R. Owen, B. Knight, L. R. Cardon, M. Walker, G. A. Hitman, A. D. Morris, A. S. F. Doney, P. R. Burton, D. G. Clayton, N. Craddock, P. Deloukas, A. Duncanson, D. P. Kwiatkowski, W. H. Ouwehand, N. J. Samani, J. A. Todd, P. Donnelly, D. Davison, D. Easton, D. Evans, H.-T. Leung, C. C. A. Spencer, M. D. Tobin, A. P. Attwood, J. P. Boorman, B. Cant, U. Everson, J. M. Hussey, J. D. Jolley, A. S. Knight, K. Koch, E. Meech, S. Nutland, C. V. Prowse, H. E. Stevens, N. C. Taylor, G. R. Walters, N. M. Walker, N. A. Watkins, T. Winzer, R. W. Jones, W. L. McArdle, S. M. Ring, D. P. Strachan, M. Pembrey, G. Breen, D. St. Clair, S. Caesar, K. Gordon-Smith, L. Jones, C. Fraser, E. K. Green, D. Grozeva, M. L. Hamshere, P. A. Holmans, I. R. Jones, G. Kirov, V. Moskvina, I. Nikolov, M. C. O'Donovan, M. J. Owen, D. A. Collier, A. Elkin, A. Farmer, R. Williamson, P. McGuffin, A. H. Young, I. N. Ferrier, S. G. Ball, A. J. Balmforth, J. H. Barrett, D. T. Bishop, M. M. Iles, A. Maqbool, N. Yuldasheva, A. S. Hall, P. S. Braund, R. J. Dixon, M. Mangino, S. Stevens, J. R. Thompson, F. Bredin, M. Tremelling, M. Parkes, H. Drummond, C. W. Lees, E. R. Nimmo, J. Satsangi, S. A. Fisher, A. Forbes, C. M. Lewis, C. M. Onnie, N. J. Prescott, J. Sanderson, C. G. Mathew, J. Barbour, M. K. Mohiuddin, C. E. Todhunter, J. C. Mansfield, T. Ahmad, F. R. Cummings, D. P. Jewell, J. Webster, M. J. Brown, G. M. Lathrop, J. Connell, A. Dominiczak, C. A. Braga Marcano, B. Burke, R. Dobson, J. Gungadoo, K. L. Lee, P. B. Munroe, S. J. Newhouse, A. Onipinla, C. Wallace, M. Xue, M. Caulfield, M. Farrall, A. Barton, I. N. Bruce, H. Donovan, S. Eyre, P. D. Gilbert, S. L. Hider, A. M. Hinks, S. L. John, C. Potter, A. J. Silman, D. P. M. Symmons, W. Thomson, J. Worthington, D. B. Dunger, B. Widmer, M. Newport, G. Sirugo, E. Lyons, F. Vannberg, A. V. S. Hill, L. A. Bradbury, C. Farrar, J. J. Pointon, P. Wordsworth, M. A. Brown, J. A. Franklyn, J. M. Heward, M. J. Simmonds, S. C. L. Gough, S. Seal, M. R. Stratton, N. Rahman, M. Ban, A. Goris, S. J. Sawcer, A. Compston, D. Conway, M. Jallow, K. A. Rockett, S. J. Bumpstead, A. Chaney, K. Downes, M. J. R. Ghori, R. Gwilliam, S. E. Hunt, M. Inouye, A. Keniry, E. King, R. McGinnis, S. Potter, R. Ravindrarajah, P. Whittaker, C. Widden, D. Withers, N. J. Cardin, T. Ferreira, J. Pereira-Gale, I. B. Hallgrimsdottir, B. N. Howie, Z. Su, Y. Y. Teo, D. Vukcevic, D. Bentley, A. Compston, N. J. Ouwehand, M. R. Samani, J. D. Isaacs, A. W. Morgan, G. D. Wilson, A. Ardern-Jones, J. Berg, A. Brady, Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes Science. ,vol. 316, pp. 1336- 1341 ,(2007) , 10.1126/SCIENCE.1142364
Krina T Zondervan, Lon R Cardon, None, The complex interplay among factors that influence allelic association Nature Reviews Genetics. ,vol. 5, pp. 89- 100 ,(2004) , 10.1038/NRG1270
Nicole A R Walter, Shannon K McWeeney, Sandra T Peters, John K Belknap, Robert Hitzemann, Kari J Buck, SNPs matter: impact on detection of differential expression Nature Methods. ,vol. 4, pp. 679- 680 ,(2007) , 10.1038/NMETH0907-679
I. A. Eaves, L. S. Wicker, G. Ghandour, P. A. Lyons, L. B. Peterson, J. A. Todd, R. J. Glynne, Combining Mouse Congenic Strains and Microarray Gene Expression Analyses to Study a Complex Trait: The NOD Model of Type 1 Diabetes Genome Research. ,vol. 12, pp. 232- 243 ,(2002) , 10.1101/GR.214102
Leah C. Solberg, William Valdar, Dominique Gauguier, Graciela Nunez, Amy Taylor, Stephanie Burnett, Carmen Arboledas-Hita, Polinka Hernandez-Pliego, Stuart Davidson, Peter Burns, Shoumo Bhattacharya, Tertius Hough, Douglas Higgs, Paul Klenerman, William O. Cookson, Youming Zhang, Robert M. Deacon, J. Nicholas P. Rawlins, Richard Mott, Jonathan Flint, A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice. Mammalian Genome. ,vol. 17, pp. 129- 146 ,(2006) , 10.1007/S00335-005-0112-1
Richard Mott, Jörg Schultz, Peer Bork, Chris P Ponting, Predicting Protein Cellular Localization Using a Domain Projection Method Genome Research. ,vol. 12, pp. 1168- 1174 ,(2002) , 10.1101/GR.96802
John A Todd, Neil M Walker, Jason D Cooper, Deborah J Smyth, Kate Downes, Vincent Plagnol, Rebecca Bailey, Sergey Nejentsev, Sarah F Field, Felicity Payne, Christopher E Lowe, Jeffrey S Szeszko, Jason P Hafler, Lauren Zeitels, Jennie HM Yang, Adrian Vella, Sarah Nutland, Helen E Stevens, Helen Schuilenburg, Gillian Coleman, Meeta Maisuria, William Meadows, Luc J Smink, Barry Healy, Oliver S Burren, Alex AC Lam, Nigel R Ovington, James Allen, Ellen Adlem, Hin-Tak Leung, Chris Wallace, Joanna MM Howson, Cristian Guja, Constantin Ionescu-Tîrgovişte, Genetics of Type 1 Diabetes in Finland, Matthew J Simmonds, Joanne M Heward, Stephen CL Gough, David B Dunger, Wellcome Trust Case Control Consortium, Linda S Wicker, David G Clayton, Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics. ,vol. 39, pp. 857- 864 ,(2007) , 10.1038/NG2068