Is There a Survival Benefit to Adjuvant Radiotherapy in High-Risk Surgical Stage I Endometrial Cancer?

摘要: Abstract Objective. The aim of this study was to examine the effects therapeutic modalities on survival stage I endometrial cancer and also evaluate surgical morbidity prognostic importance surgicopathological variables. Methods. A hundred ninety-six patients treated at Hacettepe University Hospital between 1982 1997 were included. After initial diagnosis all underwent procedures including peritoneal cytology, infracolic omentectomy, total abdominal hysterectomy, bilateral salphingoopherectomy, complete pelvic–paraaortic lymphadenectomy. mean age 56 years (SD = 9.9 years) followed 3–18 (median, 8 years). All had endometrioid carcinoma. Stage IC and/or grade 3 tumors considered high-risk factors by definition 147 (75%) low risk 49 (25%) high risk. Forty-nine percent received adjuvant radiotherapy compared with 3.5% in low-risk group. Results. 10-year disease-free overall rates entire group 97 98%, respectively. Ten-year rate for 100% 94% features ( P 0.002). 96% 24 who versus 92% 25 did not receive therapy 0.53). Only a significant predictor poor 0.0004). Overall 8.1% without mortality related surgery. Conclusions. Surgical staging achieved excellent incurring untoward mortality. No advantage detected even patients, so we suggest use may be reserved relapse.