Schizophrenia pathophysiology: are we any closer to a complete model?

摘要: Schizophrenia, a severe brain disorder that involves hallucinations, disordered thinking and deficiencies in cognition, has been studied for decades order to determine the early events lead this neurological disorder. In review, we interpret developmental genetic models have proposed treatment options associated with these models. Schizophrenia was initially thought be hereditary based on studies of high incidence certain families. Additionally, specific genes such as ZDHHC8 DTNBP1 seem suggest susceptibility onset However, no single gene variation linked schizophrenia, recent evidence sporadic cases schizophrenia refutes genetics being singular cause disease. addition, current data suggests neurodevelopmental or environmental causes viral infections prenatal/perinatal complications. Before any can understood, however, multiple cognitive neuroscientific accommodate from many biomedical research fields should considered, unfortunately, are earliest stages development. Consequently, it makes us question whether closer an adequate understanding pathophysiology schizophrenia.