Cys2His2 Zinc Finger Methyl-CpG Binding Proteins: Getting a Handle on Methylated DNA.

摘要: DNA methylation is an essential epigenetic modification involved in the maintenance of genomic stability, preservation cellular identity, and regulation transcriptional landscape needed to maintain function. In increasing number disease conditions, patterns are inappropriately distributed a manner that supports phenotype. Methyl-CpG binding proteins (MBPs) specialized transcription factors read translate methylated signals into recruitment protein assemblies can alter local chromatin architecture transcription. MBPs thus play key intermediary role gene for both normal diseased cells. Here, we highlight established potential structure-function relationships best characterized members zinc finger (ZF) family propagating downstream responses. Current future investigations aimed toward expanding our understanding ZF MBP roles will provide mechanistic insight state functions, as well afford evaluation these epigenetic-based therapeutic targets.